“NAD+ in aging, metabolism, and neurodegeneration,” Verdin, 2015
This review article provides background on the biosynthesis and salvage pathway of NAD+, as well as its role as a coenzyme in relation to sirtuins and Poly(ADP-ribose) polymerases.
“Age-Associated Changes In Oxidative Stress and NAD+Metabolism In Human Tissue,” Massudi et al., 2012
This study shows that in human tissue, NAD+ levels and sirtuin activity decrease with age. Since DNA damage increases as we age, the DNA repair enzyme (PARP) activity also increases in response. Additionally, as PARP enzymes are NAD+ dependent, this increase in activity leads to NAD+ decline as one ages.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042357
“NAD+ and sirtuins in aging and disease,” Imai, Guarente (2016)
This paper focuses on the relationship between the sirtuins and NAD+ in aging.
https://www.ncbi.nlm.nih.gov/pubmed/24786309
To read our published clinical trial that demonstrated the safety and efficacy of Basis, please visit: https://www.elysiumhealth.com/en-us/basis/human-clinical-trial-results
For an additional list of journal articles on NAD+, sirtuins, and more, please refer to “The Science Behind Basis” section here:
https://www.elysiumhealth.com/en-us/basis/how-basis-works
We also recommend reading this Science 101 post for more information about NAD+: