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What journal articles would you recommend reading?

“NAD+ in aging, metabolism, and neurodegeneration,” Verdin, 2015

This review article provides background on the biosynthesis and salvage pathway of NAD+, as well as its role as a coenzyme in relation to sirtuins and Poly(ADP-ribose) polymerases.

http://static1.squarespace.com/static/5612e1b6e4b0e1ea753984e7/t/56b9498e8259b5b7fc7560a9/1454983567239/2015+Science+review.pdf

 

“Age-Associated Changes In Oxidative Stress and NAD+Metabolism In Human Tissue,” Massudi et al., 2012

This study shows that in human tissue, NAD+ levels and sirtuin activity decrease with age. Since DNA damage increases as we age, the DNA repair enzyme (PARP) activity also increases in response. Additionally, as PARP enzymes are NAD+ dependent, this increase in activity leads to NAD+ decline as one ages.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042357

 

“NAD+ and sirtuins in aging and disease,” Imai, Guarente (2016)

This paper focuses on the relationship between the sirtuins and NAD+ in aging.

https://www.ncbi.nlm.nih.gov/pubmed/24786309

 

To read our published clinical trial that demonstrated the safety and efficacy of Basis, please visit: https://www.elysiumhealth.com/en-us/basis/human-clinical-trial-results

 

For an additional list of journal articles on NAD+, sirtuins, and more, please refer to “The Science Behind Basis” section here:

https://www.elysiumhealth.com/en-us/basis/how-basis-works

 

We also recommend reading this Science 101 post for more information about NAD+:

https://www.elysiumhealth.com/en-us/knowledge/science-101/everything-you-need-to-know-about-nicotinamide-adenine-dinucleotide-nad