Article One
Note: While our most popular guides have been translated into Spanish, some guides are only available in English.

What journal articles would you recommend reading?

“NAD+ in aging, metabolism, and neurodegeneration,” Verdin, 2015

This review article provides background on the biosynthesis and salvage pathway of NAD+, as well as its role as a coenzyme in relation to sirtuins and Poly(ADP-ribose) polymerases.


“Age-Associated Changes In Oxidative Stress and NAD+Metabolism In Human Tissue,” Massudi et al., 2012

This study shows that in human tissue, NAD+ levels and sirtuin activity decrease with age. Since DNA damage increases as we age, the DNA repair enzyme (PARP) activity also increases in response. Additionally, as PARP enzymes are NAD+ dependent, this increase in activity leads to NAD+ decline as one ages.


“NAD+ and sirtuins in aging and disease,” Imai, Guarente (2016)

This paper focuses on the relationship between the sirtuins and NAD+ in aging.


To read our published clinical trial that demonstrated the safety and efficacy of Basis, please visit:


For an additional list of journal articles on NAD+, sirtuins, and more, please refer to “The Science Behind Basis” section here:


We also recommend reading this Science 101 post for more information about NAD+: