We recommend taking two Basis capsules every morning, with or without food. Studies indicate that NAD+ levels are circadian in nature and show a peak during the wake cycle. By taking Basis in the morning, you are allowing the increase in NAD+ levels from Basis to coincide with your body’s normal peak of NAD+. Many customers tell us that making Basis part of their morning routine works best, especially because some report a slight rise in energy after taking it. The most important thing to remember is to take Basis daily for best results, as cellular health optimizes over time.